Vogt Virus Lab at the University of North Carolina
We study the pathogenesis of viral diseases in children and the immune response.
AREAS OF FOCUS
Virology
Enterovirus D68
Enteroviruses
Rhinoviruses
Parechoviruses
Immunology
Interferons
Antibodies
Pathogenesis
Respiratory tract
Central nervous system
Translational
Acute flaccid myelitis
Human monoclonal antibodies
Newborn viral sepsis and encephalitis
FEATURED PROJECTS
Enhanced Outbreak Modeling
By enrolling children in the Pandemic REsponse REpository through Microbial and Immune Surveillance and Epidemiology (PREMISE) study, we dramatically improve virus circulation forecasts.
Enterovirus D68 Infection Pathogenesis
Typically causing the common cold, EV-D68 also causes the polio-like disease acute flaccid myelitis. We investigate how this happens.
Human Monoclonal Antibodies to Treat Acute Flaccid Myelitis
We have shown in mice that these therapies can prevent and treat AFM in mice. Now we are working to translate this to humans.
Enterovirus Cross-reactive Antibodies
By focusing on identifying human monoclonal antibodies that bind to many different enteroviruses, we hope to translate these findings to broader therapies and better vaccines.
Pandemic Preparedness
As a member of the Bunyavirus and Picornavirus Pandemic Pathogen Preparedness Center of the Research and Development of Vaccines and Monoclonal Antibodies for Pandemic Preparedness network, we generate anti-picornavirus human monoclonal antibodies.