Vogt Virus Lab at the University of North Carolina
We study the pathogenesis of viral diseases in children and the immune response.
AREAS OF FOCUS
Virology
Enterovirus D68
Enteroviruses
Rhinoviruses
Parechoviruses
Immunology
Interferons
Antibodies
Pathogenesis
Respiratory tract
Central nervous system
Translational
Acute flaccid myelitis
Human monoclonal antibodies
Newborn viral sepsis and encephalitis
KEY PROJECTS
Enterovirus D68 Infection Pathogenesis
Typically causing the common cold, EV-D68 also causes the polio-like disease acute flaccid myelitis. We investigate how this happens.
Human Monoclonal Antibodies to Treat Acute Flaccid Myelitis
We have shown in mice that these therapies can prevent and treat AFM in mice. Now we are working to translate this to humans.
Enterovirus Cross-reactive Antibodies
By focusing on identifying human monoclonal antibodies that bind to many different enteroviruses, we hope to translate these findings to broader therapies and better vaccines.